Role of incidental and/or cured intestinal parasitic infections on profile of CD4(+) and CD8(+) T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians
| Autor: | Beyene Petros, Aster Tsegaye, T F Rinke de Wit, A L Fontanet, Mathias Aklilu, Dawit Wolday, Eduard J. Sanders, Dörte Hamann, Afework Kassu, D. van Baarle |
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| Přispěvatelé: | Global Health, Landsteiner Laboratory, Infectious diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male T cell Immunology Context (language use) HIV Infections Biology CD8-Positive T-Lymphocytes Lymphocyte Activation Peripheral blood mononuclear cell Statistics Nonparametric T-Lymphocyte Subsets Immunopathology medicine Immunology and Allergy Cytotoxic T cell Humans Lymphocyte Count Intestinal Diseases Parasitic Original Articles Middle Aged Flow Cytometry Virology medicine.anatomical_structure T cell differentiation Case-Control Studies biology.protein HIV-1 Female Ethiopia Antibody CD8 Follow-Up Studies |
| Zdroj: | Clinical and experimental immunology, 132(1), 113-119. Wiley-Blackwell |
| ISSN: | 0009-9104 |
| DOI: | 10.1046/j.1365-2249.2003.02106.x |
| Popis: | SUMMARYIntestinal parasitic infections have been suggested to cause persistent immune activation leading to an unbalanced immune state. Such a state has been proposed to be a major factor in the pathogenesis of AIDS in an African context. The present study investigated the effect of incidental parasitic infection and treatment on the profile of T cell differentiation and activation markers on CD4+ and CD8+ T cells from HIV-1 infected and uninfected adult Ethiopians. Cryopreserved PBMCs from 64 subjects (41 HIV-negative and 23 HIV-positive) with follow-up visits at 6-monthly intervals were used to compare the effect of incidental intestinal parasites and their treatment upon T cell subset profiles and activation status. The samples were stained with antibodies to various T cell differentiation and activation markers allowing naive, memory, effector, memory/effector, activated and resting CD4+ and CD8+ T cell subsets to be quantified by triple-colour FACScan. Incidental intestinal parasitic infections resulted in a significant increase in memory CD4+ T cell numbers both in HIV-negative and HIV-positive subjects (P peripheral blood. Treatment of parasitic infections showed a tendency to reduce the activation suggesting that, together with other community based intervention strategies, such treatment could be used to down-regulate immune activation and hence protect the host from being easily attacked by HIV. |
| Databáze: | OpenAIRE |
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