Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds
| Autor: | Abayomi O. Adetuyi, Ganiyu Oboh, Stephen A. Adefegha, Toyin L. Akomolafe |
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| Rok vydání: | 2009 |
| Předmět: |
Antioxidant
Free Radicals Bilirubin medicine.medical_treatment Toxicology medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Pathology and Forensic Medicine chemistry.chemical_compound Picrates In vivo medicine Animals Food science Ferrous Compounds Cyclophosphamide biology Dose-Response Relationship Drug Plant Extracts Biphenyl Compounds Bixaceae Brain Water Cell Biology General Medicine Malondialdehyde biology.organism_classification Rats Oxidative Stress chemistry Biochemistry Seeds Alkaline phosphatase Liver function Chloroform Lipid Peroxidation Oxidative stress Injections Intraperitoneal |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 63(3) |
| ISSN: | 1618-1433 |
| Popis: | Annatto (Bixa orellana) seeds are widely distributed throughout the Tropics and have been used to provide both colour and flavour to food. This study sought to assess the ability of dietary inclusion of polar (water) and non-polar (chloroform) extracts of Annatto (B. orellana) seeds on cyclophosphamide-induced oxidative stress in rat brain. The total phenol content and antioxidant activities of polar (water) and non-polar (chloroform) extracts of Annatto seeds were determined in vitro and in vivo. The results of the study showed that intraperitoneal administration of cyclophosphamide (75 mg/kg of body weight) caused a significant increase (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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