Adverse cardiac events during catecholamine vasopressor therapy: a prospective observational study
| Autor: | Martin W. Dünser, Christian Torgersen, Daniel C. H. Schröder, Ingo H. Lorenz, C A Schmittinger, Günter Luckner |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Myocardial Ischemia Critical Care and Intensive Care Medicine law.invention Pathogenesis Catecholamines law Heart Rate Internal medicine Anesthesiology Tachycardia medicine Humans Vasoconstrictor Agents Renal replacement therapy Prospective Studies Simplified Acute Physiology Score Aged Mechanical ventilation business.industry Incidence (epidemiology) Middle Aged Intensive care unit Anesthesia Catecholamine Cardiology Female business medicine.drug |
| Zdroj: | Schmittinger, Christian A; Torgersen, Christian; Luckner, Günter; Schröder, Daniel C H; Lorenz, Ingo; Dünser, Martin W (2012). Adverse cardiac events during catecholamine vasopressor therapy: a prospective observational study. Intensive care medicine, 38(6), pp. 950-958. Berlin: Springer-Verlag 10.1007/s00134-012-2531-2 |
| Popis: | PURPOSE: To determine the incidence of and risk factors for adverse cardiac events during catecholamine vasopressor therapy in surgical intensive care unit patients with cardiovascular failure. METHODS: The occurrence of any of seven predefined adverse cardiac events (prolonged elevated heart rate, tachyarrhythmia, myocardial cell damage, acute cardiac arrest or death, pulmonary hypertension-induced right heart dysfunction, reduction of systemic blood flow) was prospectively recorded during catecholamine vasopressor therapy lasting at least 12 h. RESULTS: Fifty-four of 112 study patients developed a total of 114 adverse cardiac events, an incidence of 48.2 % (95 % CI, 38.8-57.6 %). New-onset tachyarrhythmia (49.1 %), prolonged elevated heart rate (23.7 %), and myocardial cell damage (17.5 %) occurred most frequently. Aside from chronic liver diseases, factors independently associated with the occurrence of adverse cardiac events included need for renal replacement therapy, disease severity (assessed by the Simplified Acute Physiology Score II), number of catecholamine vasopressors (OR, 1.73; 95 % CI, 1.08-2.77; p = 0.02) and duration of catecholamine vasopressor therapy (OR, 1.01; 95 % CI, 1-1.01; p = 0.002). Patients developing adverse cardiac events were on catecholamine vasopressors (p |
| Databáze: | OpenAIRE |
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