Effect of varying the type of fat in a semi-purified AIN-76A diet on cellular proliferation in the mammary gland and intestinal crypts in female Swiss Webster mice
| Autor: | E. McMullen, E. Lok, W.M.N. Ratnayake, S. Fernie, Fraser W. Scott, R. Mongeau, E.A. Nera, P. Jee, D.B. Clayson, S. Malcolm |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
medicine.medical_specialty food.ingredient Ratón Linoleic acid Mammary gland Crypt Cod Liver Oil Biology Antioxidants Soybean oil Linoleic Acid Mice chemistry.chemical_compound Fish Oils Mammary Glands Animal food Internal medicine medicine Animals Safflower Oil food and beverages Organ Size General Medicine Cod liver oil Hyperplasia medicine.disease Fish oil Dietary Fats digestive system diseases Intestines medicine.anatomical_structure Endocrinology Linoleic Acids chemistry Splenomegaly Female Cell Division Spleen Thymidine |
| Zdroj: | Carcinogenesis. 13:1735-1741 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/13.10.1735 |
| Popis: | Young virgin female Swiss Webster mice were fed AIN-76A semi-purified diets containing equal weights of different fats for approximately 30 days. Using [3H]thymidine radioautography, it was established that mice fed 100% lard or high levels of fish oils (menhaden oil or cod liver oil) developed elevated cellular proliferation in the duct cells of the mammary gland and an increased number of labeled cells/crypt in the crypts of the colo-rectum accompanied by an increase in the size of the proliferative compartment. A possible inverse correlation between the level of [3H]thymidine labeling in the mammary gland, but not in the colo-rectum, and the linoleic acid content of individual diets may help to explain the significance of these observations. The effect of adding an antioxidant mixture to these diets was to reduce the excess proliferation induced in the intestinal crypts by lard or fish oil to the level induced by soybean oil, but only partially so in the duct cells of the mammary gland. |
| Databáze: | OpenAIRE |
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