Rate of hourly change in serum beta-human chorionic gonadotropin levels in ectopic pregnancy can predict the success of treatment with single-dose methotrexate: A retrospective observational study
| Autor: | G. Lavie, M. Kais, Rene Tendler, Avishalom Sharon, Jacob Bornstein, O. Marwan |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Tertiary referral centre Chorionic Gonadotropin Pregnancy medicine Humans Chorionic Gonadotropin beta Subunit Human Beta human chorionic gonadotropin Retrospective Studies Abortifacient Agents Nonsteroidal Ectopic pregnancy Obstetrics business.industry Obstetrics and Gynecology Retrospective cohort study medicine.disease Pregnancy Ectopic Methotrexate Reproductive Medicine Population study Female Gonadotropin business medicine.drug |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 265 |
| ISSN: | 1872-7654 |
| Popis: | To determine whether the success of treatment with single-dose methotrexate (SD MTX) for ectopic pregnancy can be predicted using the rate of change in serum β-human chorionic gonadotropin (β-hCG) level.This was a retrospective observational study conducted at a tertiary referral centre. The study population included women who underwent treatment with SD-MTX for ectopic pregnancy. We analysed data of 119 women treated with SD-MTX for ectopic pregnancy at the Galilee Medical Centre between 2012 and 2016. Success was defined as a15% decrease in β-hCG level between days 4 and 7, with no need for a second dose of MTX or surgical intervention. The dynamics of serum β-hCG levels before treatment were considered as the main outcomes.SD-MTX administration was successful in 77 (65%) patients. The average baseline β-hCG level was significantly lower in women with successful outcomes than in those without successful outcomes (763.1 vs. 1429.63 mIU/L, respectively, p 0.0048). The hourly change in β-hCG level was significantly lower in those with successful outcomes than in those without successful outcomes (0.38 vs. 5.73 mIU/mL, respectively, p 0.0023). The percentage change in β-hCG level was 13.1%, which was not significantly different between the groups (p 0.133). At serum β-hCG level 946 mIU/mL and sac size 2.55 cm, the treatment was successful in 88% of women.We propose a predictive model of hourly change in β-hCG to achieve successful treatment using SD-MTX in ectopic pregnancy based on objective and measurable criteria. |
| Databáze: | OpenAIRE |
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