Magnetic resonance methods as a prognostic tool for the biorelevant behavior of xanthan tablets

Autor: Urša Mikac, Julijana Kristl
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Chemistry
Pharmaceutical

Pharmaceutical Science
02 engineering and technology
magnetna resonanca
030226 pharmacology & pharmacy
Analytical Chemistry
Matrix (chemical analysis)
0302 clinical medicine
Drug Delivery Systems
hidrofilne matrične tablete
Drug Discovery
drug release
Drug Carriers
medicine.diagnostic_test
Chemistry
Polysaccharides
Bacterial

Hydrogels
021001 nanoscience & nanotechnology
Prognosis
Controlled release
Magnetic Resonance Imaging
biorelevant dynamic conditions
Chemistry (miscellaneous)
Drug delivery
Drug release
dostavni sistemi
Molecular Medicine
Swelling
medicine.symptom
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Tablets
Article
hydrophilic matrix tablets
lcsh:QD241-441
magnetic resonance
03 medical and health sciences
hidrogeli
lcsh:Organic chemistry
medicine
Physical and Theoretical Chemistry
udc:537.635:615.015.14
sproščanje učinkovin
Organic Chemistry
Water
Magnetic resonance imaging
Models
Theoretical

High stress
Drug Liberation
Solubility
Drug Design
hydrogel
Oral retinoid
Biomedical engineering
Zdroj: Molecules, vol. 25, no. 24, 5871, 2020.
Molecules
Volume 25
Issue 24
Molecules, Vol 25, Iss 5871, p 5871 (2020)
ISSN: 1420-3049
Popis: Hydrophilic matrix tablets with controlled drug release have been used extensively as one of the most successful oral drug delivery systems for optimizing therapeutic efficacy. In this work, magnetic resonance imaging (MRI) is used to study the influence of various pHs and mechanical stresses caused by medium flow (at rest, 80, or 150 mL/min) on swelling and on pentoxifylline release from xanthan (Xan) tablets. Moreover, a bimodal MRI system with simultaneous release testing enables measurements of hydrogel thickness and drug release, both under the same experimental conditions and at the same time. The results show that in water, the hydrogel structure is weaker and less resistant to erosion than the Xan structure in the acid medium. Different hydrogel structures affect drug release with erosion controlled release in water and diffusion controlled release in the acid medium. Mechanical stress simulating gastrointestinal contraction has no effect on the hard hydrogel in the acid medium where the release is independent of the tested stress, while it affects the release from the weak hydrogel in water with faster release under high stress. Our findings suggest that simultaneous MR imaging and drug release from matrix tablets together provide a valuable prognostic tool for prolonged drug delivery design.
Databáze: OpenAIRE