Magnetic resonance methods as a prognostic tool for the biorelevant behavior of xanthan tablets
Autor: | Urša Mikac, Julijana Kristl |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
Chemistry
Pharmaceutical Pharmaceutical Science 02 engineering and technology magnetna resonanca 030226 pharmacology & pharmacy Analytical Chemistry Matrix (chemical analysis) 0302 clinical medicine Drug Delivery Systems hidrofilne matrične tablete Drug Discovery drug release Drug Carriers medicine.diagnostic_test Chemistry Polysaccharides Bacterial Hydrogels 021001 nanoscience & nanotechnology Prognosis Controlled release Magnetic Resonance Imaging biorelevant dynamic conditions Chemistry (miscellaneous) Drug delivery Drug release dostavni sistemi Molecular Medicine Swelling medicine.symptom 0210 nano-technology Hydrophobic and Hydrophilic Interactions Tablets Article hydrophilic matrix tablets lcsh:QD241-441 magnetic resonance 03 medical and health sciences hidrogeli lcsh:Organic chemistry medicine Physical and Theoretical Chemistry udc:537.635:615.015.14 sproščanje učinkovin Organic Chemistry Water Magnetic resonance imaging Models Theoretical High stress Drug Liberation Solubility Drug Design hydrogel Oral retinoid Biomedical engineering |
Zdroj: | Molecules, vol. 25, no. 24, 5871, 2020. Molecules Volume 25 Issue 24 Molecules, Vol 25, Iss 5871, p 5871 (2020) |
ISSN: | 1420-3049 |
Popis: | Hydrophilic matrix tablets with controlled drug release have been used extensively as one of the most successful oral drug delivery systems for optimizing therapeutic efficacy. In this work, magnetic resonance imaging (MRI) is used to study the influence of various pHs and mechanical stresses caused by medium flow (at rest, 80, or 150 mL/min) on swelling and on pentoxifylline release from xanthan (Xan) tablets. Moreover, a bimodal MRI system with simultaneous release testing enables measurements of hydrogel thickness and drug release, both under the same experimental conditions and at the same time. The results show that in water, the hydrogel structure is weaker and less resistant to erosion than the Xan structure in the acid medium. Different hydrogel structures affect drug release with erosion controlled release in water and diffusion controlled release in the acid medium. Mechanical stress simulating gastrointestinal contraction has no effect on the hard hydrogel in the acid medium where the release is independent of the tested stress, while it affects the release from the weak hydrogel in water with faster release under high stress. Our findings suggest that simultaneous MR imaging and drug release from matrix tablets together provide a valuable prognostic tool for prolonged drug delivery design. |
Databáze: | OpenAIRE |
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