Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior
| Autor: | Jei Wei Wu, Jen Kun Cheng, Robert G. Averkin, Gábor Tamás, Kai Yi Wang, Cheng Chang Lien, Kazu Nakazawa, Wai Yi Wong, Chun Chung Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fibromyalgia
Patch-Clamp Techniques Interneuron QH301-705.5 avoidance behavior Hippocampus Mice Transgenic interneuron Hippocampal formation behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology Glutamatergic GABA Mice medicine mossy cell Animals Biology (General) GABAergic Neurons CA1 Region Hippocampal Behavior Animal Chemistry Dentate gyrus Granule cell humanities Mice Inbred C57BL Optogenetics Disease Models Animal medicine.anatomical_structure Anxiogenic Dentate Gyrus Mossy Fibers Hippocampal chemogenetics Calcium Pyramidal cell Chronic Pain Neuroscience |
| Zdroj: | Cell Reports, Vol 36, Iss 11, Pp 109702-(2021) |
| ISSN: | 2211-1247 |
| Popis: | Summary: Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG, glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells (GCs) and mediate the feedback excitation and inhibition of GCs. However, the circuit mechanism by which MCs regulate anxiety-related information routing through hippocampal circuits remains unclear. Moreover, the correlation between MC activity and anxiety states is unclear. In this study, we first demonstrate, by means of calcium fiber photometry, that MC activity in the ventral hippocampus (vHPC) of mice increases while they explore anxiogenic environments. Next, juxtacellular recordings reveal that optogenetic activation of MCs preferentially recruits GABAergic neurons, thereby suppressing GCs and ventral CA1 neurons. Finally, chemogenetic excitation of MCs in the vHPC reduces avoidance behaviors in both healthy and anxious mice. These results not only indicate an anxiolytic role of MCs but also suggest that MCs may be a potential therapeutic target for anxiety disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|