Serum levels of interleukin-1 alpha, interleukin-1 beta, interleukin-6, and tumor necrosis factor in patients with acute viral hepatitis
| Autor: | Giancarla Bonetta, Claudia Zeroli, Giulio Ferrario, Roberto Tambini, Giovanni Paolo Fiori, Donate Torre, M Giola |
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| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
Adult Male Adolescent Hepatitis Viral Human medicine.medical_treatment Alpha (ethology) Medicine Humans Interleukin 6 Hepatitis biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Interleukin Hepatitis A medicine.disease Hepatitis B Hepatitis C Infectious Diseases Cytokine Immunology Acute Disease biology.protein Tumor necrosis factor alpha Female Viral disease business Viral hepatitis Interleukin-1 |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 18(2) |
| ISSN: | 1058-4838 |
| Popis: | Serum levels of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in patients with acute viral hepatitis were investigated. Twelve patients suffering from acute viral hepatitis were studied; 8 patients presented with acute hepatitis B, 2 patients with acute hepatitis A, and 2 patients with acute hepatitis C. Serum levels of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were significantly increased in all patients with acute viral hepatitis. Decreased serum levels of all cytokines were noted in four patients with acute hepatitis B during the recovery phase of infection. In addition, IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were undetectable at the end of a follow-up period of 6 months. Our study shows that increased levels of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha are probably related to hepatitis activity and thus may have some role in hepatocytic injury. |
| Databáze: | OpenAIRE |
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