Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status
| Autor: | Didem Barlak Keti, Sabahattin Muhtaroglu, Sema Nur Taşkın, Mhd Boshr Alesh, Ayşenur Paç Kısaarslan |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Familial Mediterranean fever Inflammation medicine.disease_cause Gastroenterology vitamin D deficiency Negatively associated Internal medicine medicine Vitamin D and neurology Humans Subclinical inflammation In patient Vitamin D Child business.industry General Medicine Vitamins medicine.disease Oxidants Familial Mediterranean Fever Oxidative Stress Cross-Sectional Studies medicine.symptom business Oxidative stress |
| Popis: | © TÜBİTAK.Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investigate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period. Materials and methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included. Patients were grouped according to their vitamin D status (< 20, 20–29, and 30–100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status. Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30–100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was observed between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥ 0.640) and high TOS levels were negatively associated with vitamin D levels. Conclusion: Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF during an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF. |
| Databáze: | OpenAIRE |
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