Structural Gray and White Matter Differences in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia
| Autor: | Frederic Sampedro, Beatriz Gómez-Ansón, Nicole Stantonyonge, Saul Martinez-Horta, Ana Chico, Jorge Maté Méndez |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Health Knowledge Attitudes Practice Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry 030209 endocrinology & metabolism Neuroimaging Brain damage Hypoglycemia Biochemistry White matter 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Internal medicine Fractional anisotropy medicine Humans Cognitive Dysfunction Cognitive decline Gray Matter Aged Type 1 diabetes medicine.diagnostic_test business.industry Biochemistry (medical) Magnetic resonance imaging Middle Aged medicine.disease Prognosis White Matter medicine.anatomical_structure Cross-Sectional Studies Diabetes Mellitus Type 1 Spain Cardiology Female medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 106(2) |
| ISSN: | 1945-7197 |
| Popis: | Context Type 1 diabetes (T1D) is associated with an increased risk of cognitive decline, where severe hypoglycemia (SH) and impaired awareness of hypoglycemia (IAH) may play a role. While there is evidence of a possible association between IAH and brain damage, the potential brain changes remain poorly characterized by magnetic resonance imaging (MRI). Objective To investigate whether there are structural brain differences in a group of T1D patients with IAH compared with normal awareness of hypoglycemia (NAH). Design General practice, population-based, cross-sectional study (July 2018 to July 2019). Setting Endocrinology Department, Hospital Santa Creu i Sant Pau. Participants A total of 40 T1D patients (20 each with IAH and NAH) matched for age, sex, T1D duration, and education level. Main Outcome Measures Using different neuroimaging techniques, we compared whole-brain gray matter (GM) and white matter (WM) differences. We used voxel-based morphometry and cortical surface area analysis methods to assess GM differences, and fractional anisotropy (FA) to assess WM differences. Results Compared with patients with T1D-NAH, patients with T1D-IAH had reduced GM volumes and cortical surface areas, especially in frontal and parietal regions (P Conclusions MRI for patients with T1D show that IAH is associated with brain changes involving both GM and WM. Further research is needed to elucidate whether the observed differences are a consequence of increased SH episode frequency and increased IAH severity. |
| Databáze: | OpenAIRE |
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