Coexistence of Graves' disease, papillary thyroid carcinoma and unilateral benign struma ovarii: Case report and review of the literature
| Autor: | Athina Gkiomisi, Rosaria-Maddalena Ruggeri, Alfredo Campennì, Stergios Papachatzopoulos, Dimitra Molyva, Christos Balaris, Athanasios D. Anastasilakis, Stergios A. Polyzos, Panagiotis P. Fotiadis, Polyzois Makras, Giovanni Tuccari |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease medicine.medical_treatment Hyperthyroidism Meigs syndrome Pleural effusion Thyroid cancer TSH receptor Thyroid carcinoma Endocrinology Internal medicine medicine Humans Meigs' syndrome Thyroid Neoplasms Benign Struma Ovarii Thyroid cancer Ovarian Neoplasms Struma ovarii business.industry Carcinoma Thyroid Thyroidectomy Middle Aged medicine.disease Carcinoma Papillary Graves Disease Struma Ovarii eye diseases medicine.anatomical_structure Thyroid Cancer Papillary Female business |
| Popis: | Background Struma ovarii is a rare cause of hyperthyroidism, while coexistence with Graves’ disease has been scarcely reported. Patient Findings We report a patient with Graves’ disease and unilateral benign functioning struma ovarii, accompanied by ascites, pleural effusion and elevated cancer antigen-125 (CA-125) levels. In subsequent thyroidectomy, incidental papillary thyroid carcinoma was also identified. The functionality of struma ovarii tissue in our patient was supported by the immunohistochemical identification of TSH receptors (TSHR), which may stimulate growth and thyroid hormone production in the presence of circulating TSHR stimulating antibodies (TSHR-Ab). Review of the literature A systematic review of reported cases of coexistent Graves’ disease and struma ovarii was performed. Conclusions The diagnosis of struma ovarii may be masked by Graves’ disease and, therefore, be delayed for several years. Furthermore, ascites, pleural effusion and increased CA-125 may result from a benign struma ovarii. The presence of TSHR in the struma ovarii tissue along with their absence in the surrounding ovarian tissue indirectly suggests that struma ovarii is functional. It is unclear whether TSHR-Ab play a role in the development of thyroid carcinomas in such patients. |
| Databáze: | OpenAIRE |
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