Clinical assessment of gastric emptying and sensory function utilizing gamma scintigraphy: Establishment of reference intervals for the liquid and solid components of the Nottingham test meal in healthy subjects

Autor:	Dieter Menne, Mark A. Fox, Luca Marciani, Helen L. Parker, Alan C. Perkins, Elaine Blackshaw, Emily Tucker, Caroline L. Hoad
Rok vydání:	2017
Předmět:	Adult Blood Glucose Male Adolescent Physiology Visual analogue scale Population Satiety Response 03 medical and health sciences Young Adult 0302 clinical medicine Gamma scintigraphy Reference Values Medicine Humans education Radionuclide Imaging Aged Aged 80 and over Meal education.field_of_study Gastric emptying Endocrine and Autonomic Systems business.industry Stomach digestive oral and skin physiology Gastroenterology Middle Aged Postprandial Period Reference intervals medicine.anatomical_structure Postprandial Gastric Emptying 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Nuclear medicine business gamma scintigraphy gastric emptying visceral sensitivity
Zdroj:	Neurogastroenterology and motility, 2017, Vol.29(11), pp.e13122 [Peer Reviewed Journal]
ISSN:	1365-2982 1350-1925
Popis:	Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study presents the reference intervals of the modular “Nottingham test meal” (NTM) for assessment of gastric function by gamma scintigraphy (GSc) in a representative population of healthy volunteers (HVs) stratified for age and sex. Methods: The NTM comprises 400 mL liquid nutrient (0.75 kcal/mL) and an optional solid component (12 solid agar-beads (0 kcal). Filling and dyspeptic sensations were documented by 100 mm visual analogue scale (VAS). Gamma scintigraphy parameters that describe early and late phase Gastric emptying (GE) were calculated from validated models. Key Results: Gastric emptying (GE) of the liquid component was measured in 73 HVs (male 34; aged 45±20). The NTM produced normal postprandial fullness (VAS ≥30 in 41/74 subjects). Dyspeptic symptoms were rare (VAS ≥30 in 2/74 subjects). Gastric emptying half-time with the Liquid- and Solid-component -NTM was median 44 (95% reference interval 28-78) minutes and 162 (144-193) minutes, respectively. Gastric accommodation was assessed by the ratio of the liquid-NTM retained in the proximal:total stomach and by Early phase emptying assessed by gastric volume after completing the meal (GCV0). No consistent effect of anthropometric measures on GE parameters was present. Conclusions and Inferences: Reference intervals are presented for GSc measurements of gastric motor and sensory function assessed by the NTM. Studies involving patients are required to determine whether the reference interval range offers optimal diagnostic sensitivity and specificity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ed36687ec9b85cb3fe2b4c88e756e1 https://pubmed.ncbi.nlm.nih.gov/28589661 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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