Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes

Autor: Rinke Stienstra, Mihai G. Netea, Gil Leibowitz, Yael Riahi, Assaf Rudich, Yulia Haim
Rok vydání: 2014
Předmět:
endoplasmic-reticulum stress
Endocrinology
Diabetes and Metabolism
kappa-b
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Adipose tissue
Cellular homeostasis
Inflammation
Type 2 diabetes
Biology
Voeding
Metabolisme en Genomica
chemistry.chemical_compound
Insulin resistance
Voeding
Insulin-Secreting Cells
protective role
Adipocyte
Autophagy
Internal Medicine
medicine
Humans
Obesity
glucose
Nutrition
VLAG
pathway
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
unfolded protein response
medicine.disease
Metabolism and Genomics
Cell biology
proinflammatory response
Adipose Tissue
Diabetes Mellitus
Type 2
chemistry
Metabolisme en Genomica
Immunology
Nutrition
Metabolism and Genomics
Insulin Resistance
medicine.symptom
Beta cell
metabolism
insulin-secretion
pancreatic b-cell
Zdroj: Diabetologia 57 (2014) 8
Diabetologia, 57, 8, pp. 1505-16
Diabetologia, 57, 1505-16
Diabetologia, 57(8), 1505-1516
ISSN: 0012-186X
Popis: Item does not contain fulltext Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.
Databáze: OpenAIRE
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