Outcomes of post-prostatectomy radiotherapy at a Regional Cancer Centre

Autor:	Eric Khoo, Luke Nicholls, Preeti Bagga, Ashley Plank, Ashley Harwood, Amber Winter, Winnie Wong
Rok vydání:	2017
Předmět:	Biochemical recurrence Male medicine.medical_specialty Surgical margin medicine.medical_treatment Urology Adenocarcinoma radiation therapy Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Postoperative Period Aged Aged 80 and over Prostatectomy Radiological and Ultrasound Technology business.industry Australia Prostatic Neoplasms Original Articles Middle Aged medicine.disease regional cancer centre Surgery Radiation therapy Prostate-specific antigen 030220 oncology & carcinogenesis Toxicity Original Article Radiotherapy Intensity-Modulated Rural Health Services business
Zdroj:	Journal of Medical Radiation Sciences
ISSN:	2051-3909
Popis:	Introduction To investigate the efficacy and toxicity of radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer at Radiation Oncology Centres, Toowoomba. Methods The electronic medical records of 130 consecutive patients with histologically proven prostate adenocarcinoma who underwent post‐prostatectomy RT between January 2008 and December 2014 were analysed. Primary endpoint was Biochemical Recurrence (BCR) after RT. BCR was defined by PSA > 0.2 ng/mL and BCR endpoints were analysed using Kaplan–Meier methods. The impact of RT technique and the rates of acute and late toxicities are also reported. Toxicities were graded according to Radiation Therapy Oncology Group (RTOG) criteria. Results Median follow‐up time after RT (regardless of technique) was 28 months. BCR occurred in 32 of the 126 patients (25%) whose prostate specific antigen (PSA) levels have been monitored post‐RT. At 24 and 36 months, 85% and 75% of patients were BCR‐free, respectively. Patients with a pre‐RT PSA above 0.2 ng/mL had a higher probability of recurrence than patients with values below 0.2 ng/mL (P = 0.03). RT technique, pelvic nodal irradiation, androgen deprivation therapy, T staging or surgical margin did not significantly impact BCR results. No patient experienced acute toxicities greater than grade 2. Grade 1 or 2 late gastrointestinal (GI) toxicity occurred in 11% and 1 patient experienced a grade 3 event. 12% of patients developed grade 1 or 2 late genitourinary (GU) toxicity, with evidence of grade 3 severity in only 1 patient. Evidence of a trend in reduction in late GI toxicity with the use of intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) was apparent but not with late GU toxicity. Conclusion At our regional centre, early RT (PSA
Databáze:	OpenAIRE
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