Effect of Successive Administration of Vancomycin and Amikacin on Auditory Function of Immature Animals
| Autor: | O. V. Kamkina, I. N. D’yakonova, D. S. Burmistrova, I. V. Rakhmanova, Yu. S. Ishanova |
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| Rok vydání: | 2017 |
| Předmět: |
Single administration
Time Factors medicine.drug_class Otoacoustic Emissions Spontaneous Antibiotics Otoacoustic emission Pharmacology Weight Gain General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Vancomycin 030225 pediatrics Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases Animals Medicine Auditory function Outer hair cells Amikacin business.industry General Medicine Anti-Bacterial Agents Hair Cells Auditory Outer Auditory brainstem response Anesthesia Rabbits sense organs business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 162:458-461 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-017-3639-8 |
| Popis: | Effect of successive administration vancomycin and amikacin in therapeutic doses on immature auditory organ was compared to single administration of the same drugs in chronic experiments on immature rabbits by recording of short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Drug administration always increased significantly the ABR peak I threshold. Ototoxic antibiotics did not change DPOAE, but selectively affected activity of outer hair cells. No enhancement of the ototoxic effects was observed after successive administration of the two antibiotics. |
| Databáze: | OpenAIRE |
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