REVERSIBLE INFERTILITY, PHARMACEUTICAL AND SPONTANEOUS, IN A MALE WITH LATE ONSET CONGENITAL ADRENAL HYPERPLASIA, DUE TO 21-HYDROXYLASE DEFICIENCY
| Autor: | Dimitrios Panidis, I Kalachanis, G Makedos, F Goutzioulis, Anargyros Kourtis, David Rousso |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Infertility medicine.medical_specialty Pediatrics Physical examination Dexamethasone Male infertility Endocrinology medicine Humans Congenital adrenal hyperplasia Infertility Male Gynecology Pregnancy Adrenal Hyperplasia Congenital biology medicine.diagnostic_test business.industry 21-Hydroxylase medicine.disease biology.protein Female Steroid 21-Hydroxylase business Glucocorticoid medicine.drug |
| Zdroj: | Archives of Andrology. 48:37-41 |
| ISSN: | 0148-5016 |
| Popis: | The authors describe a case of a 35-year-old man with 5-year duration infertility. History, clinical examination, and laboratory tests have established the diagnosis of late-onset congenital adrenal hyperplasia, due to 21-hydroxylase deficiency. Treatment with dexamethasone resulted in improvement of sperm quality, and 4 months later a pregnancy was achieved. Two years after the patient fathered his first child, and while he had discontinued dexamethasone treatment, he succeeded at a second pregnancy. The authors conclude that (1) late-onset congenital adrenal hyperplasia presents with significant variation during the patient's lifetime; (2) glucocorticoid administration is necessary in infertile men with nonclassic form of 21-hydroxylase deficiency; and (3) in cases of male infertility of unknown origin, the patient must be scrutinized for congenital adrenal hyperplasia, especially the nonclassic form. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|