Predictors of hemorrhagic transformation occurring in patients with cardioembolic ischemic stroke
| Rok vydání: | 2016 |
|---|---|
| Předmět: |
medicine.medical_specialty
Necrosis кардіоемболічний інсульт lcsh:Medicine Cathepsin D Neurological examination Matrix metalloproteinase medicine.disease_cause Gastroenterology Blood serum Internal medicine medicine окисний стрес геморагічна трансформація АФК+-лейкоцити Stroke катепсин D medicine.diagnostic_test business.industry lcsh:R General Medicine medicine.disease Apoptosis гострий період medicine.symptom business Oxidative stress |
| Zdroj: | ScienceRise: Medical Science, Vol 0, Iss 6 (2), Pp 26-32 (2016) |
| ISSN: | 2519-4798 2519-478X |
| DOI: | 10.15587/2519-4798.2016.72033 |
| Popis: | Aim. To specify the role of certain clinical factors, active forms of oxygen (AFO) and Cathepsin D as predictors of hemorrhagic transformation occurring at cardioembolic ischemic stroke (CEIS). Methods. Clinical and neurological examination of 125 patients with CEIS in the acute stage was carried out. The number of leukocytes in the stage of apoptosis (АNV+-cells) and necrosis (PI+-cells), the number of leukocytes with high AFO intracellular content (AFO+-cells) and low mitochondrial membrane potential (MMP) (Mito+-cells), and Cathepsin D activity were determined. Results. Clinical and laboratory characteristics of CEIS in patients with hemorrhagic transformation (HT) were determined. Both severe stroke, and disorders of consciousness, and large stroke volume-heart size, and SBP is over than 170 mm Hg refer to clinical factors associated with HT. The number of AFO+-leukocytes and Cathepsin D activity in blood serum during the first day of the disease should be used as additional markers to predict cardioembolic ischemic stroke hemorrhagic transformation. When the count of AFO+-leukocytes is over than 40 %, along with Cathepsin D total activity, higher than 4.5, and Cathepsin D free activity, higher than 3.5 nmol of tyrosine. Conclusion. The number of leukocytes with high AFO intracellular content and Cathepsin D activity in blood serum during the first day of cardioembolic ischemic stroke can be predictors of hemorrhagic transformation progress. Determination of hemorrhagic transformation predictors should be carried out before the thrombolytic and anticoagulant therapy |
| Databáze: | OpenAIRE |
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