Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke
| Autor: | Mohammad Reza Bigdeli, Abbas Aliaghaei, Sepideh Khaksar, Mahmoud Ramdan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Mesenchymal Stem Cell Transplantation Blood–brain barrier Umbilical cord Brain Ischemia 03 medical and health sciences 0302 clinical medicine Animal model Internal medicine Animals Humans Medicine cardiovascular diseases Rats Wistar Stroke Cause of death business.industry General Medicine medicine.disease Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neurology Infarct volume Cardiology Neurology (clinical) Stem cell business 030217 neurology & neurosurgery |
| Zdroj: | Neurological Research. 43:225-238 |
| ISSN: | 1743-1328 0161-6412 |
| DOI: | 10.1080/01616412.2020.1839698 |
| Popis: | Stroke, a cerebrovascular disease, has been introduced as the second cause of death and physical disability in the world. Recently, cell-based therapy has been considered by the scientific community as a promising strategy for reducing ischemic damages. The stem cells of the umbilical cord release growth and neurotrophic factors. The remarkable properties of these cells are the reason why they were selected as a potential candidate in the present research.In this study, the impact of transplanting umbilical cord stem cells on injuries resulting from ischemia was investigated. The male rats were categorized into three major. Using stereotaxic surgery, stem cells were injected to the right striatum of the brain. One week after transplantation, cerebral ischemic induction surgery was performed. The rats in the transplantation + ischemia group were separately divided into distinct sub-groups to explore the score of the neurological deficits, infarction volume, integrity of the blood-brain barrier, and brain edema.In this study, a significant decrease was observed in the neurological deficits of the transplantation + ischemia group compared with those of the control group. Similarly, the volume of infarction, the permeability of the blood-brain barrier, and edema were significantly reduced in the transplantation + ischemia group in comparison with those of the control group.The pretreatment of the transplanted umbilical cord stem cells in the striatum of ischemic rats possibly leads to restorative events, exerting a decreasing effect on cell death. Subsequently, these events may improve the motor ability and reduce ischemic injuries. |
| Databáze: | OpenAIRE |
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