Simultaneous Eye Tracking and Single-Neuron Recordings in Human Epilepsy Patients
| Autor: | Nand Chandravadia, Shuo Wang, Adam N. Mamelak, Ueli Rutishauser |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
genetic structures Eye Movements Computer science General Chemical Engineering Cognitive neuroscience Article General Biochemistry Genetics and Molecular Biology Task (project management) 03 medical and health sciences 0302 clinical medicine Memory medicine Animals Humans Attention Visual search Neurons Epilepsy General Immunology and Microbiology General Neuroscience Eye movement Neurophysiology Electrophysiology 030104 developmental biology medicine.anatomical_structure Eye tracking Female Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | J Vis Exp |
| ISSN: | 1940-087X |
| DOI: | 10.3791/59117-v |
| Popis: | Intracranial recordings from patients with intractable epilepsy provide a unique opportunity to study the activity of individual human neurons during active behavior. An important tool for quantifying behavior is eye tracking, which is an indispensable tool for studying visual attention. However, eye tracking is challenging to use concurrently with invasive electrophysiology and this approach has consequently been little used. Here, we present a proven experimental protocol to conduct single-neuron recordings with simultaneous eye tracking in humans. We describe how the systems are connected and the optimal settings to record neurons and eye movements. To illustrate the utility of this method, we summarize results that were made possible by this setup. This data shows how using eye tracking in a memory-guided visual search task allowed us to describe a new class of neurons called target neurons, whose response was reflective of top-down attention to the current search target. Lastly, we discuss the significance and solutions to potential problems of this setup. Together, our protocol and results suggest that single-neuron recordings with simultaneous eye tracking in humans are an effective method to study human brain function. It provides a key missing link between animal neurophysiology and human cognitive neuroscience. |
| Databáze: | OpenAIRE |
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