Co-encapsulation of acyclovir and curcumin into microparticles improves the physicochemical characteristics and potentiates in vitro antiviral action: Influence of the polymeric composition
| Autor: | André Gündel, Marcel Henrique Marcondes Sari, Thaina Accarini, Eduardo André Bender, Mario Celso Sperrotto Brum, Sandra Elisa Haas, Gabriel Pedroso Viçozzi, Jéssica Brandão Reolon, Letícia Marques Colomé, Maicon Brustolin |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Curcumin media_common.quotation_subject Drug Compounding Acrylic Resins Pharmaceutical Science Acyclovir 02 engineering and technology 030226 pharmacology & pharmacy Antiviral Agents Cell Line 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hypromellose Derivatives Animals Solubility media_common Herpesvirus 1 Bovine chemistry.chemical_classification Drug Carriers Chemistry Drug Synergism Polymer 021001 nanoscience & nanotechnology In vitro Drug Liberation Biopharmaceutical Chemical engineering Spray drying Cattle 0210 nano-technology Drug carrier |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 131 |
| ISSN: | 1879-0720 |
| Popis: | The present study developed and characterized microparticles formulations containing acyclovir and curcumin co-encapsulated in order to overcome the biopharmaceutical limitations and increase the antiviral effect of both drugs. The microparticles were prepared by a spray drying methodology following the ratio 1:3 (drug:polymer), which were made by hydroxypropylmethylcellulose (HPMC) and/or Eudragit® RS100 (EUD). The MP-1 formulation was composed of HPMC and EUD (1:1), MP-2 formulation was composed only of HPMC and MP-3 formulation was composed only of EUD. All formulations showed yielding around 50% and acceptable powder flowability. Drug content determination around 82.1–96.8% and 81.8–87% for acyclovir and curcumin, respectively. The microparticles had spherical shape, size within 11.5–15.3 μm, unimodal distribution and no chemical interactions among the components of the formulations. Of particular importance, the polymeric composition considerably influenced on the release profile of the drugs. The in vitro release experiment demonstrated that the microencapsulation provided a sustained release of acyclovir as well as increased the solubility of curcumin. Besides, mathematical modeling indicated that the experimental fit biexponential equation. Importantly, drugs microencapsulation promoted superior antiviral effect against BoVH-1 virus in comparison to their free form, which could be attributed to the improvement in the aforementioned physicochemical parameters. Therefore, these formulations could be promising technological drug carriers for acyclovir and curcumin, which highlight the great offering a potential alternative treatment for viral herpes. |
| Databáze: | OpenAIRE |
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