Identification of four new DR52-associated DRB1 alleles: DRB1*1424, *1425, *1323 and *1324
| ISSN: | 0001-2815 |
|---|---|
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e051c02cc57ff4d0c18d81a3e8accd https://pubmed.ncbi.nlm.nih.gov/9243754 |
| Rights: | CLOSED |
| Přírůstkové číslo: | edsair.doi.dedup.....35e051c02cc57ff4d0c18d81a3e8accd |
| Autor: | J. M. Mason, J. Wang, Ting Tang, D. Sese, U. Heine, F.-M. Robbins, J. M. Ellis, Edgar L. Milford, Carolyn Katovich Hurley |
| Rok vydání: | 1997 |
| Předmět: |
musculoskeletal diseases
Immunology Molecular Sequence Data Human leukocyte antigen Biology Biochemistry DNA sequencing Exon immune system diseases Genetics Immunology and Allergy Humans Gene conversion Allele skin and connective tissue diseases Alleles chemistry.chemical_classification Polymorphism Genetic Base Sequence General Medicine DNA HLA-DR Antigens Molecular biology Amino acid chemistry HLA-DRB1 Chains |
| Zdroj: | Tissue antigens. 50(1) |
| ISSN: | 0001-2815 |
| Popis: | Four previously unreported DR52-associated DRB1 alleles have been characterized through DNA sequencing, contributing to the diversity of the HLA system. DRB1*1424 is nearly identical to DRB1*1402 in the second exon, except that it contains the "I---A" motif found at codons 67-71 common to the DRB1*15 alleles. DRB1*1425 contains the "A--H" motif, found in DRB1*1401 at codons 57-60, in a sequence otherwise identical with the second exon of DRB1*1307. Compared with DRB1*11012, DRB1*1323 contains three predicted amino acid changes at codons 58 (ala-->glu), 67 (phe-->ile), and 71 (arg-->glu). The sequence of DRB1*1324 is identical to exon 2 of DRB1*1103, except that DRB1*1324 does not contain the GAG at codon 58 characteristic of the DRB1*11 alleles. These new alleles may have arisen through gene conversion, and they contribute to the complexity of the DR6 family. |
| Databáze: | OpenAIRE |
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