Subtle Cognitive Deficits Are Associated with Amyloid-β Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Study

Autor:	Seon Young Ryu, Yun Jeong Hong, SeongHee Ho, Jee Hyang Jeong, Kee Hyung Park, SangYun Kim, Min Jeong Wang, Seong Hye Choi, Dong Won Yang
Rok vydání:	2022
Předmět:	Psychiatry and Mental health Amyloid beta-Peptides Cognition Alzheimer Disease Positron-Emission Tomography hemic and lymphatic diseases Cognitive Neuroscience Humans Cognitive Dysfunction Self Report Neuropsychological Tests Geriatrics and Gerontology Aged
Zdroj:	Dementia and Geriatric Cognitive Disorders. 51:159-167
ISSN:	1421-9824 1420-8008
DOI:	10.1159/000523971
Popis:	Introduction: Subjective cognitive decline (SCD) can be considered as the preclinical manifestation of Alzheimer’s disease (AD). The National Institute on Aging and the Alzheimer’s Association criteria for preclinical AD proposed that subtle cognitive changes appear along with AD biomarkers in the late stage of preclinical AD. The objective of this study was to explore whether subtle cognitive impairment (SCI) in individuals with SCD is associated with brain amyloid-β (Aβ) status and SCD severity. Methods: One hundred twenty individuals with SCD (mean age: 70.87 ± 6.10 years) were included in this study. SCI was defined as performance ≤ −1.0 SD on at least two neuropsychological tests. Participants underwent an amyloid positron emission tomography, which was assessed visually and quantitatively using standardized uptake value ratio (SUVR). The severity of SCD was assessed using two self-reported questionnaires: the SCD questionnaire based on the SCD-plus features and the Korean-Everyday Cognition (K-ECog) scale. Results: SCD individuals with SCI (n = 25) had more Aβ positivity than the SCD only group (n = 95) (44% vs. 15.79%; p = 0.002). In addition, the SCI group had a higher global SUVR than the SCD only group (p = 0.048). For self-reported questionnaires, there were no differences in SCD questionnaire total scores and K-ECog global and cognitive domain-specific scores between two groups. Conclusions: In SCD individuals, SCI was associated with higher Aβ positivity, but not with the severity of self-reported cognitive decline, compared to the SCD only group. These results suggest that the recognition of objectively defined subtle cognitive deficits may contribute to the early identification of AD in SCD.
Databáze:	OpenAIRE
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