Fendosal (HP 129): A potent anti-inflammatory and analgesic compound
| Autor: | J. C. Wilker, Richard C. Allen, H. B. Lassman, W. J. Novick, V. B. Anderson, Marc N. Agnew |
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| Rok vydání: | 1978 |
| Předmět: |
Allergy
Indoles medicine.drug_class Immunology Analgesic Inflammation Pharmacology Toxicology Anti-inflammatory Edema Hydroxybenzoates medicine Animals Bioassay Pharmacology (medical) Aspirin Granuloma business.industry Anti-Inflammatory Agents Non-Steroidal medicine.disease Arthritis Experimental Salicylates Rats Female Polyarthritis medicine.symptom business medicine.drug |
| Zdroj: | Agents and Actions. 8:209-217 |
| ISSN: | 1420-908X 0065-4299 |
| Popis: | Fendosal (HP 129) is one of a series of potent non-steroidal anti-inflammatory agents. Fendosal was compared with aspirin in several anti-inflammatory and analgesic bioassay procedures. Results indicate that fendosal has an anti-inflammatory activity 1.4 times greater than does aspirin in carrageenan-induced rat paw edema. Fendosal is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation. The analgesic activity of fendosal is considered to be superior to that of aspirin, with the advantage of a prolonged duration of action. The gastric-irritating properties of fendosal are very low in comparison with those of aspirin. Fendosal has a much wider separation of effective and gastric-irritating doses than does aspirin. |
| Databáze: | OpenAIRE |
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