Toward clinical trials of DNA vaccines against malaria
| Autor: | Denise L. Doolan, Jon Norman, Thong P. Le, Libia F Scheller, Stephen L. Hoffman, Ruobing Wang, Dennis M. Klinman, Richard C. Hedstrom, Peter Hobart, Martha Sedegah, Anita Kumar, Walter R. Weiss |
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| Rok vydání: | 1997 |
| Předmět: |
Plasmodium falciparum
Immunology Antigens Protozoan CD8-Positive T-Lymphocytes Biology DNA vaccination Mice parasitic diseases Vaccines DNA medicine Animals Immunology and Allergy Clinical Trials as Topic Malaria vaccine Liver Diseases Immunogenicity Vaccination Cell Biology medicine.disease biology.organism_classification Macaca mulatta Virology Malaria Clinical trial Circumsporozoite protein Immunity Active |
| Zdroj: | Immunology and Cell Biology. 75:376-381 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1997.59 |
| Popis: | In mid 1997 the first malaria DNA vaccine will enter clinical trials. This single gene DNA vaccine encoding the Plasmodium falciparum circumsporozoite protein (PfCSP) will be studied for safety and immunogenicity. If these criteria are met, a multi-gene DNA vaccine designed to induce protective CD8+ T cell responses against P. falciparum infected hepatocytes will be subsequently assessed for safety, immunogenicity and capacity to protect immunized volunteers against experimental challenge with P. falciparum sporozoites. Our perspectives on malaria vaccine development in general, and on a multi-gene DNA vaccine in particular, have been recently reviewed. Herein, we review the rationale and experimental foundation for the anticipated P. falciparum DNA vaccine trials. |
| Databáze: | OpenAIRE |
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