Effect of a Novel High Fiber Rice Diet on 24-Hour Glycemic Responses in Asian Indians Using Continuous Glucose Monitoring: A Randomized Clinical Trial
| Autor: | Nagarajan Lakshmipriya, Mookambika Ramya Bai, Ranjit Mohan Anjana, Christiani Jeyakumar Henry, Viswanathan Mohan, Kamala Krishnaswamy, Vasudevan Sudha, Rajagopal Gayathri, Shobana Shanmugam, Ranjit Unnikrishnan |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Dietary Fiber Male Endocrinology Diabetes and Metabolism India 030209 endocrinology & metabolism Type 2 diabetes law.invention 03 medical and health sciences 0302 clinical medicine Endocrinology Animal science Randomized controlled trial law Diabetes mellitus medicine Humans 030212 general & internal medicine Glycemic Cross-Over Studies Continuous glucose monitoring business.industry Blood Glucose Self-Monitoring food and beverages Oryza Middle Aged Overweight medicine.disease Medical Laboratory Technology Glycemic index Diabetes Mellitus Type 2 Glycemic Index White rice Female business |
| Zdroj: | Diabetes technologytherapeutics. 21(4) |
| ISSN: | 1557-8593 |
| Popis: | We have recently demonstrated a medium glycemic index for novel high fiber white rice (HFWR) variety compared to regular white rice (RWR). However, substituting HFWR for RWR during the whole day's diet may provide extended benefits. The current study aims to assess the 24 h glycemic responses of a HFWR diet compared to a RWR diet.Continuous glucose monitoring (CGM) was used to assess the glycemic profile in 18 overweight, non-diabetic Asian Indians aged 25 to 50 in a randomized cross-over design. The volunteers were provided with iso-caloric (≈2100 kcal/day) HFWR or RWR based diets for four continuous days and switched diets after appropriate washout. Fasting blood samples for insulin assessments were collected at baseline and at the end of 4 day feeding. The glucose response in terms of incremental area under the curve (IAUC) was recorded. General linear model was used to assess the adjusted mean change of fasting insulin level of HFWR compared to RWR. Age and sex were adjusted as confounders in the model.The average 24 h glucose response for HFWR was significantly lower (IAUC 66.3 ± 3.1 mg-5 min/dL) than RWR (IAUC 79.8 ± 5.7 mg-5 min/dL). The adjusted mean change in fasting insulin levels from baseline was also lower for HFWR compared to RWR. HFWR elicited a 34% and 30% lower 24 h glycemic and insulin response respectively, compared to RWR.Replacing RWR with HFWR may be a healthier alternative for Asian Indians who are at a higher risk of developing type 2 diabetes. |
| Databáze: | OpenAIRE |
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