Dipole source analysis suggests selective modulation of the supplementary motor area contribution to the readiness potential
| Autor: | M. W. I. M. Horstink, Peter Praamstra, Dick F. Stegeman, Alexander R. Cools |
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| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Central Nervous System algemeen [Geneeskunde] Logic Models Neurological Farmacotherapie van psychomotorische ziektebeelden fundamenteel en toegepast onderzoek Contingent Negative Variation Medical sciences Central Nervous System Diseases Medical Modulation (music) medicine Humans Psychology De planning van beweging bij de ziekte van Parkinson een Event-Related Potentials onderzoek Bescherming en bevordering van de menselijke gezondheid Dominance Cerebral GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Niet-toepassingsgericht onderzoek Pharmacology Behavior Supplementary motor area Movement (music) Animal General Neuroscience Motor Cortex Neurosciences Psychology Medical Geneeskunde: algemeen Pharmacotherapy of psychomotor diseases fundamental and applied research SMA Life sciences Contingent negative variation Electrophysiology Functional imaging Disease Models Animal medicine.anatomical_structure Neurology Disease Models Medicine Female Neurology (clinical) Neuroscience Biologie Motor cortex |
| Zdroj: | Electroencephalography and Clinical Neurophysiology, 98, 6, pp. 468-477 Electroencephalography and Clinical Neurophysiology, 98, 468-477 Electroencephalography and Clinical Neurophysiology, 98, pp. 468-477 |
| ISSN: | 0013-4694 |
| Popis: | The readiness potential preceding voluntary movement is modulated by the mode of movement selection, i.e. it has a higher amplitude preceding freely selected than before prescribed movements (Praamstra, P., Stegeman, D.F., Horstink, M.W.I.M., Brunia, C.H.M. and Cools, A.R. Movement-related potentials preceding voluntary movement are modulated by the mode of movement selection. Exp. Brain Res., 1995, 103: 429-439). One cortical area that is likely to be involved in this modulation is the supplementary motor area (SMA). Recent attempts to elucidate the neural generators of the readiness potential using spatiotemporal dipole source analysis, however, failed to establish a significant SMA contribution to the readiness potential. This might be explained by a failure of the proposed analyses to discriminate between SMA and motor cortex contributions to the readiness potential. We applied a dipole source analysis approach that better separates these overlapping source activities. The resulting source model includes an SMA source generating pre-movement activity consistent with evidence from intracranial recordings in humans. The SMA source accounts almost completely for the modulation of the readiness potential by different modes of movement selection. On the basis of these results, the relation between scalp-recorded movement-related activity, intracranially recorded potentials, and findings from functional imaging studies of voluntary movement, appears more transparent than suggested by previous dipole source analyses of premovement potentials. |
| Databáze: | OpenAIRE |
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