Continuous flow contact lens delivery of gentamicin to rabbit cornea and aqueous humor
| Autor: | Marcelo Avaria, Rodney P.N. Willoughby, Rajiv Bindlish, Prasanta K. Basu, David S. Rootman, Mel Krajden |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Contact Lenses
medicine.medical_treatment Pharmacology Dosage form Aqueous Humor Cornea Drug Delivery Systems Medicine Animals Pharmacology (medical) Antibacterial agent business.industry Aqueous humour Aminoglycoside Eye drop Contact lens Ophthalmology medicine.anatomical_structure Anesthesia Gentamicin sense organs Rabbits Gentamicins Ophthalmic Solutions business psychological phenomena and processes medicine.drug |
| Zdroj: | Journal of ocular pharmacology. 8(4) |
| ISSN: | 8756-3320 |
| Popis: | The Morgan Therapeutic Lens (MTL) was investigated as a continuous corneal perfusion system in New Zealand white rabbits. Gentamicin concentration in the cornea and aqueous humor delivered by the MTL was compared to gentamicin drops (13.6 mg/ml) administered every 15 or 30 minutes. Gentamicin (1 mg/ml) or 5 mg/ml was perfused at 10 ml/hr for up to 4.0 hours. At each time interval of 0.5, 1, 2 and 4 hours, homogenized corneas and aqueous humour were assayed for gentamicin concentrations. The highest aqueous humour gentamicin concentrations of 57.99 +/- 12.86 micrograms/ml were significantly higher with the MTL and 5 mg/ml of gentamicin compared with the MTL and 1 mg/ml of gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. Highest corneal concentrations of gentamicin of 496.04 +/- 101.16 micrograms/gm cornea were significantly higher with MTL and 5 mg/ml of gentamicin compared with the MTL and 1 mg/ml gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. All mean gentamicin concentrations attained via the MTL exceeded the mean inhibitory concentration for most sensitive bacterial species. The MTL is a reliable drug delivery system with distinct advantages, and may be a useful therapeutic modality in the ocular delivery of gentamicin and other drugs. |
| Databáze: | OpenAIRE |
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