Sampling and analytical strategies in on-line bioprocess monitoring and control

Autor:	U.A.Th. Brinkman, Henk Lingeman, N. C. Van De Merbel
Přispěvatelé:	BioAnalytical Chemistry
Rok vydání:	1996
Předmět:	Chromatography Chemistry Organic Chemistry Sampling (statistics) General Medicine Bioprocess SDG 6 - Clean Water and Sanitation Biochemistry Monitoring and control Analytical Chemistry Biotechnological process Organic molecules
Zdroj:	Journal of Chromatography A, 725, 13-27. Elsevier van de Merbel, N C, Lingeman, H & Brinkman, U A T 1996, ' Sampling and analytical strategies in bioproces monitoring and control. ', Journal of Chromatography A, vol. 725, pp. 13-27 . https://doi.org/10.1016/0021-9673(96)84622-X
ISSN:	0021-9673
DOI:	10.1016/0021-9673(96)84622-x
Popis:	The use of on-line systems for the determination of small organic molecules during biotechnological processes is reviewed. Since sampling of part of the culture medium is an inherent and crucial part of the use of on-line systems, several sampling systems are described and compared and a categorization of sampling techniques - non-membrane, dialysis and ultrafiltration - is provided. Further, several analytical approaches - based on flow-injection or chromatographic analysis - and their relative merits for on-line measurements are discussed. Selected examples from the recent scientific literature serve to illustrate the applicability for on-line monitoring and control of bioprocesses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d53a622027d46470ad0dfb9e60496d https://doi.org/10.1016/0021-9673(96)84622-x Zobrazit plný text záznamu Full Text from ScienceDirect