Involvement of L3T4+, LYT2.2+ T cell subsets and non-T cells in the resistance of mice against Trypanosoma cruzi infection
| Autor: | Martin E. Rottenberg, E.L. Segura, R.L. Cardoni |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.drug_class Ratón T-Lymphocytes T cell chemical and pharmacologic phenomena Spleen Biology Monoclonal antibody Microbiology Mice Immunity parasitic diseases medicine Splenocyte Animals Chagas Disease Trypanosoma cruzi Immunity Cellular Mice Inbred BALB C T lymphocyte biology.organism_classification Virology Infectious Diseases medicine.anatomical_structure Parasitology |
| Zdroj: | International Journal for Parasitology. 20:397-400 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/0020-7519(90)90158-j |
| Popis: | Cellular populations involved in resistance against T. cruzi infection were characterized from mice chronically infected with the parasite. Mice transfused with spleen cells (SC), nylon-wool-non-adherent spleen cells (NWNA) or sera from mice chronically infected with T. cruzi , showed an enhanced resistance against challenge with the parasite. The protective activity of NWNA but not of SC was completely abrogated by treatment with anti-Thyl.2 monoclonal antibodies (mAb) and complement (C). Pretreatment of NWNA cells from chronically infected mice with either anti-L3T4 or anti-Lyt 2.2 mAb partially reduced the transfer of resistance. When both L3T4 + and Lyt2.2 + cells were depleted from NWNA populations, transfer of resistance was abolished. These results appear to indicate that L3T4 + , Lyt2.2 + T cell subsets and non-T cells are involved in the immunity to T. cruzi . |
| Databáze: | OpenAIRE |
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