Exercise modulates heat shock protein 27 activity in diabetic cardiomyopathy
| Autor: | Huayu Shang, Manda Wang, Min Liang, Quansheng Su, Ismail Laher, Yanrong Pan, Shunchang Li, Derun Gao |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Diabetic Cardiomyopathies HSP27 Heat-Shock Proteins Diastole Diet High-Fat 030226 pharmacology & pharmacy Streptozocin General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Physical Conditioning Animal Diabetes mellitus Internal medicine Heat shock protein Diabetic cardiomyopathy Animals Humans Medicine Aerobic exercise Phosphorylation General Pharmacology Toxicology and Pharmaceutics Treadmill business.industry Myocardium Body Weight Cardiac muscle General Medicine medicine.disease Streptozotocin Lipids 030104 developmental biology medicine.anatomical_structure Endocrinology Heart Function Tests business medicine.drug |
| Zdroj: | Life Sciences. 243:117251 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2019.117251 |
| Popis: | Aims Heat shock protein 27 regulates homeostasis of skeletal and cardiac muscle proteins in various stressful states including diabetes and exercise. Aerobic exercise can inhibit or ameliorate cardiac structural abnormality and dysfunction in diabetic cardiomyopathy. The aim of this study was to evaluate the role of HSP27 in aerobic exercise improving cardiac diastolic dysfunction in type 2 diabetic rats. Methods Forty male Sprague-Dawley rats were randomly divided into the following groups: control, control + aerobic exercise, diabetic, and diabetic + aerobic exercise. Diabetes was induced by feeding with a high-fat high-sugar diet for 7-weeks followed by a single intraperitoneal injection of streptozotocin (30 mg/kg) in male rats. Moderate aerobic exercise training was performed on a treadmill for 8 weeks after induction of diabetes. Key findings Aerobic exercise increased left ventricular end-diastolic internal diameter, left ventricular end-diastolic volume, myocardial HSP27 protein expression, HSP27-S82 phosphorylation levels, pHSP27-titin binding and improved cardiac muscle fibre alignment in diabetic rats. Significance Our study indicates that moderate aerobic exercise increases HSP27 activation, improves cardiomyocyte fibre alignment and restores cardiac diastolic function. |
| Databáze: | OpenAIRE |
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