miRNAs in normal and malignant B cells
| Autor: | Ratanakanit Harnprasopwat, Takae Toyoshima, Ai Kotani, Arinobu Tojo, Toyotaka Kawamata |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
B-Lymphocytes
Lymphoma B-Cell medicine.medical_treatment Chronic lymphocytic leukemia Gene Expression Profiling Cancer Hematology Biology medicine.disease Phenotype Targeted therapy MicroRNAs medicine.anatomical_structure RNA interference microRNA Immunology Cancer research medicine Leukemia B-Cell Gene silencing Animals Humans B cell |
| Zdroj: | International journal of hematology. 92(2) |
| ISSN: | 1865-3774 |
| Popis: | MicroRNAs (miRNA) are small noncoding RNAs that posttranscriptionally regulate expression of target mRNAs. In animals, miRNAs control many developmental and physiological processes. It has recently revealed that miRNAs critically work in B cell development and some B cell malignancy and that their expression profiles well correlate with its prognosis and phenotype. This review overviews these interesting findings and discuss a possibility that miRNA is a promising target for therapeutic and diagnostic tool for B cell malignancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink