Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains
| Autor: | Danuta Idzik, Tomasz J. Wąsik, Małgorzata Kępa, Robert D. Wojtyczka, Maria Miklasińska-Majdanik |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus Gram-negative bacteria medicine.drug_class Health Toxicology and Mutagenesis Gram-positive bacteria 030106 microbiology Antibiotics lcsh:Medicine Review Microbial Sensitivity Tests medicine.disease_cause antibiotics Bacterial cell structure Microbiology 03 medical and health sciences Antibiotic resistance antibacterial activity Phenols Drug Resistance Bacterial medicine Mode of action Flavonoids Bacteria biology Plant Extracts Chemistry lcsh:R Public Health Environmental and Occupational Health Polyphenols food and beverages Drug Resistance Microbial Drug Synergism biology.organism_classification Anti-Bacterial Agents Antibacterial activity |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 15, Iss 10, p 2321 (2018) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph15102321 |
| Popis: | There is a growing body of evidence that flavonoids show antibacterial activity against both Gram-positive and Gram-negative bacteria. The mechanisms of action of phenolic compounds on bacterial cell have been partially attributed to damage to the bacterial membrane, inhibition of virulence factors such as enzymes and toxins, and suppression of bacterial biofilm formation. What is more, some natural polyphenols, aside from direct antibacterial activity, exert a synergistic effect when combined with common chemotherapeutics. Many studies have proved that in synergy with antibiotics plant flavonoids pose a promising alternative for therapeutic strategies against drug resistant bacteria. In this review most recent reports on antimicrobial action of polyphenols on Staphylococcus aureus strains are described, highlighting where proven, the mechanisms of action and the structure–activity relationships. Since many reports in this field are, to some extent, conflicting, a unified in vitro and in vivo susceptibility testing algorithms should be introduced to ensure the selection of effective antibacterial polyphenolic compounds with low cytotoxicity and minimal side effects. |
| Databáze: | OpenAIRE |
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