The serotonin transporter gene and peer-rated neuroticism
| Autor: | Rainer Riemann, L Hill, Frank M. Spinath, Jan Strelau, Thalia C. Eley, Alois Angleitner, Bernard Freeman, David Ball, Robert Plomin |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Serotonin Adolescent Genotype Neurotic Disorders Nerve Tissue Proteins Peer Group polymorphism Gene Frequency Emotionality Polymorphism (computer science) mental disorders risk factors Humans neuroticism Gene Depression (differential diagnoses) Serotonin transporter Aged Genetics Serotonin Plasma Membrane Transport Proteins Chi-Square Distribution Membrane Glycoproteins Polymorphism Genetic biology General Neuroscience Membrane Transport Proteins Middle Aged Neuroticism Variable number tandem repeat transporter depression biology.protein Psychology Carrier Proteins |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| ISSN: | 0959-4965 |
| Popis: | POLYMORPHISMS in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires.(1) We attempted to extend these findings using a selected extremes design and peer ratings. From a sample of 2085 individuals, each assessed on neuroticism by two independent peers, we selected 52 individuals from the top 5% and 54 individuals from the bottom 5%. No association was found for either a functional 44 bp insertion/deletion polymorphism in 5HTT regulatory sequence (5HTTLPR) or for a non-functional variable number tandem repeat 5HTT polymorphism. |
| Databáze: | OpenAIRE |
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