The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity
| Autor: | Kathryn M. Madalena, Jessica K. Lerch |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Nervous system Cell type Cell Plasticity Review Article Biology lcsh:RC321-571 03 medical and health sciences Receptors Glucocorticoid 0302 clinical medicine Glucocorticoid receptor medicine Animals Receptor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Glucocorticoids Microglia Glutamate receptor Brain 030104 developmental biology medicine.anatomical_structure Spinal Cord Neurology sense organs Neurology (clinical) Neuroglia Neuroscience 030217 neurology & neurosurgery Glucocorticoid medicine.drug |
| Zdroj: | Neural Plasticity Neural Plasticity, Vol 2017 (2017) |
| ISSN: | 1687-5443 2090-5904 |
| DOI: | 10.1155/2017/8640970 |
| Popis: | Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the nervous system, the expression level varies, suggesting that diverse cell types react differently to GR activation. Stress/GCs induce structural plasticity in neurons, Schwann cells, microglia, oligodendrocytes, and astrocytes as well as affect neurotransmission by changing the release and reuptake of glutamate. While general nervous system plasticity is essential for adaptation and learning and memory, stress-induced plasticity is often maladaptive and contributes to neuropsychiatric disorders and neuropathic pain. In this brief review, we describe the evidence that stress/GCs activate GR to promote cell type-specific changes in cellular plasticity throughout the nervous system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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