Identification of Novel Inhibitors for Tobacco Mosaic Virus Infection in Solanaceae Plants
| Autor: | Ramalingam Jegadeesan, Arul Loganathan, Subashini Swaminathan, Archana Prabahar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Virtual screening
Article Subject viruses fungi Biomedical Engineering RNA-dependent RNA polymerase food and beverages Biology Biochemistry Genetics and Molecular Biology (miscellaneous) Small molecule Virology Computer Science Applications chemistry.chemical_compound lcsh:Biology (General) chemistry Docking (molecular) Capping enzyme RNA polymerase Tobacco mosaic virus Movement protein lcsh:QH301-705.5 lcsh:Statistics lcsh:HA1-4737 Research Article |
| Zdroj: | Advances in Bioinformatics Advances in Bioinformatics, Vol 2015 (2015) |
| ISSN: | 1687-8035 1687-8027 |
| Popis: | Tobacco mosaic virus(TMV) infects several crops of economic importance (e.g., tomato) and remains as one of the major concerns to the farmers. TMV enters the host cell and produces the capping enzyme RNA polymerase. The viral genome replicates further to produce multiple mRNAs which encodes several proteins, including the coat protein and an RNA-dependent RNA polymerase (RdRp), as well as the movement protein. TMV replicase domain was chosen for the virtual screening studies against small molecules derived from ligand databases such as PubChem and ChemBank. Catalytic sites of the RdRp domain were identified and subjected to docking analysis with screened ligands derived from virtual screening LigandFit. Small molecules that interact with the target molecule at the catalytic domain region amino acids, GDD, were chosen as the best inhibitors for controlling the TMV replicase activity. |
| Databáze: | OpenAIRE |
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