Physical exercise protects myenteric neurons and reduces parasitemia in Trypanosoma cruzi infection
| Autor: | Caroline Felicio Braga, Jacqueline Nelisis Zanoni, Neide Martins Moreira, Márcia Machado de Oliveira Dalalio, Silvana Marques de Araújo, Eduardo José de Almeida Araújo |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Nitrergic neuron TGF-β medicine.medical_specialty Trypanosoma cruzi Immunology Myenteric Plexus Physical exercise Nitric Oxide Synthase Type I Parasitemia Mice Random Allocation Immune system Physical Conditioning Animal Internal medicine parasitic diseases medicine Animals Chagas Disease Treadmill Neurons biology General Medicine Prognosis biology.organism_classification medicine.disease Infectious Diseases Endocrinology Physical training TNF-α Exercise Test Trypanosoma Cytokines Parasitology Analysis of variance Nitrergic Neuron |
| Zdroj: | Experimental Parasitology. 141:68-74 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/j.exppara.2014.03.005 |
| Popis: | To evaluate the parasitemia, nitrergic neurons, and cytokines in Trypanosoma cruzi-infected mice subjected to moderate physical exercise, forty male Swiss mice, 30days of age, were divided: Trained Control (TC), Trained Infected (TI), Sedentary Control (SC), and Sedentary Infected (SI). The moderate physical exercise program on a treadmill lasted 8weeks. Three days after completing the moderate physical exercise program, the TI and SI groups were inoculated with 1300 blood trypomastigotes of the Y strain of T. cruzi, and parasitemia was evaluated from day 4 to day 22 after inoculation. After 75days of infection, cytokines were measured and colonic neurons were quantified using immunofluorescence to identify neuronal nitric oxide synthase (nNOS). The results were analyzed using analysis of variance – Tukey and Kruskal–Wallis tests, to 5% significance. Moderate physical exercise reduced the parasite peak on day 8 of infection and total parasitemia (p0.05), providing beneficial effects to the host by acting on the immune system to preserve nitrergic neurons. |
| Databáze: | OpenAIRE |
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