Clinical Progression of Parkinson’s Disease: Insights from the NINDS Common Data Elements

Autor:	Mechelle M. Lewis, Bethany Snyder, Xuemei Huang, Christy Stetter, Lan Kong, Eun Young Lee, Elias Harkins, Guangwei Du, Tyler Corson
Rok vydání:	2020
Předmět:	Male 0301 basic medicine medicine.medical_specialty Parkinson's disease Severity of Illness Index Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Rating scale Internal medicine medicine Humans National Institute of Neurological Disorders and Stroke (U.S.) Stroke Depression (differential diagnoses) Aged Common Data Elements business.industry Montreal Cognitive Assessment Parkinson Disease Middle Aged medicine.disease United States 030104 developmental biology Cohort Disease Progression Biomarker (medicine) Female Neurology (clinical) business 030217 neurology & neurosurgery Clinical progression
Zdroj:	J Parkinsons Dis
ISSN:	1877-718X 1877-7171
Popis:	BACKGROUND/OBJECTIVE: To synchronize data collection, the National Institute of Neurological Disorders and Stroke recommended Common Data Elements (CDEs) for use in Parkinson’s disease (PD) research. This study delineated the progression patterns of these CDEs in a cohort of PD patients. METHODS: One hundred-twenty-five PD patients participated in the PD Biomarker Program (PDBP) at Penn State. CDEs, including MDS-Unified PD Rating Scales (UPDRS)-total, questionnaire-based non-motor (-I) and motor (-II), and rater-based motor (-III) subscales; Montreal Cognitive Assessment (MoCA); Hamilton Depression Rating Scale (HDRS); University of Pennsylvania Smell Identification Test (UPSIT); and PD Questionnaire (PDQ-39) were obtained at baseline and three annual follow-ups. Annual change was delineated for PD or subgroups [early=PDE, disease duration (DD)5 y] using mixed effects model analyses. RESULTS: UPDRS-total, -II, and PDQ-39 scores increased significantly, and UPSIT decreased, whereas UPDRS-I, -III, MoCA, and HDRS did not change, over 36 months in the overall PD cohort. In the PDE subgroup, UPDRS-II increased and UPSIT decreased significantly, whereas MoCA and UPSIT decreased significantly in the PDM subgroup. In the PDL subgroup, UPDRS-II and PDQ-39 increased significantly. Other metrics within each individual subgroup did not change. Sensitivity analyses using subjects with complete data confirmed these findings. CONCLUSIONS: Among CDEs, UPDRS-total, –II, PDQ-39, and UPSIT all are sensitive metrics to track PD progression. Subgroup analyses revealed that these CDEs have distinct stage-dependent sensitivities, with UPSIT for DD5 y, UPDRS-II for early (DD 5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cdcc8e2585c3b3a7a634f8cb0b1c7c https://doi.org/10.3233/jpd-201932 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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