Contribution of presynaptic dopaminergic receptors to the mechanism of the reactivating effects of blockade of the GABA-benzodiazepine-ionophore complex
| Autor: | N. I. Dubrovina, R. Yu. Il'yuchenok |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Flumazenil
Conditioning Classical Escape response Pharmacology Bicuculline Receptors Dopamine GABA Antagonists Mice chemistry.chemical_compound Neurochemical Memory Avoidance Learning Reaction Time medicine Animals Picrotoxin GABA-A Receptor Antagonists GABA Modulators Autoreceptors Mice Inbred BALB C Ionophores GABAA receptor General Neuroscience Dopaminergic chemistry Dopamine receptor Dopamine Antagonists Haloperidol Neuroscience medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 28:294-298 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/bf02462959 |
| Popis: | Changes in the reactivating efficiency of blockade of components of the GABA-benzodiazepine-ionophore complex were analyzed in conditions of preliminary activation and inhibition of dopamine autoreceptors using (+)ZRRR and haloperidol respectively. A conditioned passive escape reflex was used, along with amnesia produced by detaining mice in the danger sector of a chamber immediately after imposition of a painful stimulus. Doses of bicuculline (1 mg/kg), picrotoxin (1 mg/kg), and flumazenil (10 mg/kg) given before testing restored performance of the conditioned response without altering the neurochemical background. Reductions and increases in dopaminergic activity during the training period prevented restoration of the conditioned passive escape response by blockade of GABAa and benzodiazepine receptors and chloride channels. It is suggested that the neurochemical mechanisms involved in restoring the damaged memory trace are based on the formation of the optimal balance in the activities of the various components of the GABA-benzodiazepine-ionophore complex and the dopaminergic system. |
| Databáze: | OpenAIRE |
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