Diagnostic test accuracy of Xpert MTB/RIF for tuberculous pericarditis: a systematic review and meta-analysis
| Autor: | Makhyan Jibril Al-Farabi, Andrianto Andrianto, Ni Made Mertaniasih, Michael Jonatan, Parama Gandi, Stevanus Immanuel Silahooij, Yusuf Azmi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Extrapulmonary TBC 030106 microbiology Xpert MTB/RIF General Biochemistry Genetics and Molecular Biology Pericardial Effusion law.invention Mycobacterium tuberculosis 03 medical and health sciences Pericarditis Randomized controlled trial law Pulmonary tuberculosis Internal medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics Randomized Controlled Trials as Topic General Immunology and Microbiology biology business.industry Diagnostic Tests Routine Tuberculous pericarditis Diagnostic test General Medicine Articles Pericarditis Tuberculous medicine.disease biology.organism_classification Observational Studies as Topic 030104 developmental biology PCR Meta-analysis Systematic Review business Cohort study |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Introduction: Xpert MTB/RIF is a rapid diagnostic instrument for pulmonary tuberculosis (TB). However, studies reported varied accuracy of Xpert MTB/RIF in detecting Mycobacterium tuberculosis in pericardial effusion. Methods: We performed a systematic review of literature in PubMed, published up to February 1, 2020, according to PRISMA guidelines. We screened cross-sectional studies, observational cohort studies, and randomized control trials that evaluated the accuracy of Xpert MTB/RIF in diagnosing TB pericarditis. Papers with noninterpretable results of sensitivity and specificity, non-English articles, and unpublished studies were excluded. The primary outcomes were the sensitivity and specificity of Xpert MTB/RIF. We conducted a quality assessment using QUADAS-2 to evaluate the quality of the studies. A bivariate model pooled the overall sensitivity, specificity, positive likelihood ratios (PLRs), and negative likelihood ratios (NLRs) of included studies. Results: In total, 581 subjects from nine studies were analyzed in this meta-analysis. Our pooled analysis showed that the overall sensitivity, specificity, PLRs and NLRs of included studies were 0.676 (95% CI: 0.580–0.759), 0.994 (95% CI: 0.919–1.000), 110.11 (95% CI: 7.65–1584.57) and 0.326 (95% CI: 0.246–0.433), respectively. Conclusions: Xpert MTB/RIF had a robust specificity but unsatisfactory sensitivity in diagnosing TB pericarditis. These findings indicated that although positive Xpert MTB/RIF test results might be valuable in swiftly distinguishing the diagnosis of TB pericarditis, negative test results might not be able to rule out TB pericarditis. Registration: PROSPERO CRD42020167480 28/04/2020 |
| Databáze: | OpenAIRE |
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