Nutrigenetics: links between genetic background and response to Mediterranean-type diets
| Autor: | Marie-Jo Amiot-Carlin, Marguerite Gastaldi, Richard Planells, Denis Lairon, Catherine Defoort, Jean-Charles Martin |
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| Přispěvatelé: | Nutriments Lipidiques et Prévention des Maladies Métaboliques, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration |
| Rok vydání: | 2009 |
| Předmět: |
SINGLE NUCLEOTIDE POLYMORPHISM
Medicine (miscellaneous) Single-nucleotide polymorphism Biology POLYMORPHISME MONONUCLEOTIDE Diet Mediterranean Polymorphism Single Nucleotide Nutrigenetics Nutrigenomics Polymorphism (computer science) Risk Factors Diabetes mellitus medicine SNP Humans Genetic Predisposition to Disease Nutritional Physiological Phenomena Genetic variability Gene INTERVENTION STUDY Genetics Nutrition and Dietetics Polymorphism Genetic Public Health Environmental and Occupational Health Genetic Variation medicine.disease GENE Obesity POLYMORPHISM [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Cholesterol Cardiovascular Diseases [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | Public Health Nutrition Public Health Nutrition, Cambridge University Press (CUP), 2009, 12 (9 A), pp.1601-1606. ⟨10.1017/S1368980009990437⟩ |
| ISSN: | 1475-2727 1368-9800 |
| Popis: | ObjectiveIt has been substantiated that the onset of most major diseases (CVD, diabetes, obesity, cancers, etc.) is modulated by the interaction between genetic traits (susceptibility) and environmental factors, especially diet. We aim to report more specific observations relating the effects of Mediterranean-type diets on cardiovascular risk factors and the genetic background of subjects.Results and conclusionsIn the first part, general concepts about nutrigenetics are briefly presented. Human genome has, overall, only marginally changed since its origin but it is thought that minor changes (polymorphisms) of common genes that occurred during evolution are now widespread in human populations, and can alter metabolic pathways and response to diets.In the second part, we report the data obtained during the Medi-RIVAGE intervention study performed in the South-East of France. Data obtained in 169 subjects at moderate cardiovascular risk after a 3-month dietary intervention indicate that some of the twenty-three single nucleotide polymorphisms (SNP) studied exhibit interactions with diets regarding changes of particular parameters after 3-month regimens. Detailed examples are presented, such as interactions between SNP in genes coding for microsomial transfer protein (MTTP) or intestinal fatty acid binding protein (FABP2) and triglyceride, LDL-cholesterol or Framigham score lowering in responses to Mediterranean-type diets.The data provided add further evidence of the interaction between particular SNP and metabolic responses to diets. Finally, improvement in dietary recommendations by taking into account known genetic variability has been discussed. |
| Databáze: | OpenAIRE |
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