XRCC3 5′-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis
| Autor: | Ping Zhan, Hai-Guang Liu, Bo Chen, Jian Zhang, Kai Xue, Hui Yuan, Xichun Hu, Chen Mao, Ke-Da Yu, Lei Yao, Li-Xin Qiu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Untranslated region Cancer Research medicine.medical_specialty Breast Neoplasms Biology Risk Assessment Breast cancer XRCC3 Risk Factors Internal medicine Genotype Odds Ratio medicine Humans Genetic Predisposition to Disease Allele Genetics Polymorphism Genetic Cancer Odds ratio medicine.disease DNA-Binding Proteins Phenotype Female Breast disease 5' Untranslated Regions |
| Zdroj: | Breast Cancer Research and Treatment. 122:489-493 |
| ISSN: | 1573-7217 0167-6806 |
| Popis: | Published data on the association between XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between these polymorphisms and breast cancer risk. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively. A total of four studies were involved in the meta-analysis with 6,303 cases and 6,563 controls for XRCC3 5'-UTR polymorphism and with 6,270 cases and 6,682 controls for XRCC3 IVS5-14 polymorphism. For XRCC3 5'-UTR A/G polymorphism, significantly elevated breast cancer risk was associated with variant genotype when all studies were pooled into the meta-analysis (AG vs. AA: OR = 1.11, 95% CI = 1.03-1.19; dominant model: OR = 1.09, 95% CI = 1.01-1.17). For XRCC3 IVS5-14 A/G polymorphism, significantly decreased breast cancer risk was associated with variant genotype (GG vs. AA: OR = 0.86, 95% CI = 0.77-0.96). In conclusion, this meta-analysis suggests that the variant G allele of XRCC3 5'-UTR polymorphism is a low-penetrant risk factor for developing breast cancer, while the variant G allele of XRCC3 IVS5-14 polymorphism has a protective effect on breast cancer development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink