Sarcoidosis Activity: Correlation of HRCT Findings with Those of67 Ga Scanning, Bronchoalveolar Lavage, and Serum Angiotensin-Converting Enzyme Assay
| Autor: | Ann N. Leung, Michel Brauner, Dominique Valeyre, Philippe Grenier, Nadine Caillat-Vigneron |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Systemic disease Serum angiotensin converting enzyme High resolution Gallium Gallium Radioisotopes Peptidyl-Dipeptidase A Scintigraphy Correlation Sarcoidosis Pulmonary medicine Humans Radiology Nuclear Medicine and imaging Citrates Radionuclide Imaging Lung Aged Retrospective Studies medicine.diagnostic_test business.industry Clinical Enzyme Tests Middle Aged respiratory system medicine.disease respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure Female Sarcoidosis Radiopharmaceuticals Tomography X-Ray Computed Nuclear medicine business Bronchoalveolar Lavage Fluid |
| Zdroj: | Journal of Computer Assisted Tomography. 22:229-234 |
| ISSN: | 0363-8715 |
| DOI: | 10.1097/00004728-199803000-00013 |
| Popis: | Purpose: The objective of this study was to correlate the findings of sarcoidosis on high resolution CT (HRCT) with indexes of disease activity as measured with 67 Ga scan, bronchoalveolar lavage (BAL), and serum angiotensin-converting enzyme (SACE) assay. Method: Twenty-nine patients with proven sarcoidosis underwent HRCT scan, 67 Ga scan. BAL, and SACE assay within a 1 month period. The extent of parenchymal involvement by nodules, consolidation, ground-glass attenuation, and linear opacities was quantified to the nearest 10% of surface area affected on the CT examination. Whole-lung gallium uptake was quantified and the percentage of BAL-recovered lymphocytes (BAL-%LC) and SACE levels obtained by chart review. CT scores of disease extent were correlated with measured indexes of activity using the Spearman rank correlation coefficient. Results: The mean extent of nodules, consolidation, ground-glass attenuation, and linear opacities on HRCT images was 15.1 ± 16.6, 1.6 ± 4.0. 17.5 ± 25.4, and 7.6 ± 9.6%, respectively. The extent of nodules and consolidation correlated with the intensity of lung gallium uptake (r = 0.46, p < 0.02), BAL-%LC (r = 0.50, p < 0.01), and SACE levels (r = 0.38, p < 0.05). No significant correlation was found between extent of ground-glass attenuation or linear opacities with any indexes of disease activity. Conclusion: On HRCT scan, nodules and consolidation in sarcoidosis reflect disease activity as measured by 67 Ga scan, BAL, and SACE assay. |
| Databáze: | OpenAIRE |
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