In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat
| Autor: | Shtaywy S. Abdalla, Amel Bouaziz, Musa H. Abu Zarga, Seddik Khennouf |
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| Rok vydání: | 2019 |
| Předmět: |
DPPH
medicine.medical_treatment Sodium Potassium Ethyl acetate chemistry.chemical_element Hypotensive Pharmacology 030226 pharmacology & pharmacy 01 natural sciences Anti-oxidant 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vitro medicine Diuretic Origanum glandulosum biology 010405 organic chemistry lcsh:RM1-950 Origanum biology.organism_classification 0104 chemical sciences lcsh:Therapeutics. Pharmacology Blood pressure chemistry Rat |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 14, Iss 1 (2019) |
| ISSN: | 1991-0088 |
| Popis: | The objective of this study was to evaluate the in vitro anti-oxidant, hypo-tensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3-methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents. |
| Databáze: | OpenAIRE |
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