Stem cells in the adult pancreas and liver
| Autor: | Zoë D. Burke, Shifaan Thowfeequ, Macarena Perán, David Tosh |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
DPPIV
dipeptidyl peptidase IV transdifferentiation Cellular differentiation Hox homeobox Clinical uses of mesenchymal stem cells Review Article CK19 cytokeratin 19 Biology liver Biochemistry Cdx1 caudal-related C/EBP CCAAT/enhancer-binding protein 03 medical and health sciences 0302 clinical medicine ES cell embryonic stem cell Cancer stem cell Pdx1 pancreatic and duodenal Hox 1 Animals Humans pancreas intestine Molecular Biology AP anterior–posterior 030304 developmental biology Stem cell transplantation for articular cartilage repair Prt Prometheus Tcf T-cell factor 0303 health sciences E embryonic day FAH fumarylacetoacetate hydrolase BMP bone morphogenetic protein Amniotic stem cells Cell Biology FGF fibroblast growth factor IHH Indian hedgehog Cell biology stem cell Intestines cell differentiation Adult Stem Cells SCID severe combined immunodeficiency 030220 oncology & carcinogenesis Amniotic epithelial cells Immunology Ngn3 neurogenin 3 HSC haematopoietic stem cell Stem cell Adult stem cell |
| Zdroj: | Biochemical Journal |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj20070167 |
| Popis: | Stem cells are undifferentiated cells that can self-renew and generate specialized (functional) cell types. The remarkable ability of stem cells to differentiate towards functional cells makes them suitable modalities in cellular therapy (which means treating diseases with the body's own cells). Potential targets for cellular therapy include diabetes and liver failure. However, in order for stem cells to be clinically useful, we must learn to identify them and to regulate their differentiation. We will use the intestine as a classical example of a stem cell compartment, and then examine the evidence for the existence of adult stem cells in two endodermally derived organs: pancreas and liver. We will review the characteristics of the putative stem cells in these tissues and the transcription factors controlling their differentiation towards functional cell types. |
| Databáze: | OpenAIRE |
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