Sestrins are evolutionarily conserved mediators of exercise benefits
| Autor: | Jun Hee Lee, Allison H. Kowalsky, Seung-Hyun Ro, Alyson Sujkowski, Susan V. Brooks, Carol S. Davis, Bondong Gu, Robert Wessells, Sim Namkoong, Michael Karin, Myungjin Kim, Ian A. Semple, Tyler Cobb, Boyoung Kim, Chun-Seok Cho |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Muscle Fibers Skeletal General Physics and Astronomy Gene Expression Cell Cycle Proteins Inbred C57BL Bioinformatics Mice 0302 clinical medicine 2.1 Biological and endogenous factors Medicine Drosophila Proteins Aetiology lcsh:Science Heat-Shock Proteins Mice Knockout Multidisciplinary Organelle Biogenesis Molecular medicine Effector TOR Serine-Threonine Kinases Cell Differentiation Skeletal Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Peroxidases Muscle Drosophila Signal transduction Oxidoreductases Signal Transduction Knockout Science Muscle Fibers General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Downregulation and upregulation Endurance training Animals Humans Obesity Exercise physiology Muscle Skeletal Protein kinase B Exercise business.industry Prevention General Chemistry Energy metabolism Mice Inbred C57BL 030104 developmental biology Metabolism Physical Endurance lcsh:Q Organelle biogenesis Energy Metabolism business Proto-Oncogene Proteins c-akt 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) Nature Communications Nature communications, vol 11, iss 1 |
| ISSN: | 2041-1723 |
| Popis: | Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways mediating the metabolic benefits of exercise have remained elusive. Here, we show that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits. In both fly and mouse models, genetic ablation of Sestrins prevents organisms from acquiring metabolic benefits of exercise and improving their endurance through training. Conversely, Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it could be a major effector of exercise metabolism. Among the various targets modulated by Sestrin in response to exercise, AKT and PGC1α are critical for the Sestrin effects in extending endurance. These results indicate that Sestrin is a key integrating factor that drives the benefits of chronic exercise to metabolism and physical endurance. Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes. |
| Databáze: | OpenAIRE |
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