Longitudinal Assessment of High Versus Low Levels of Fractional Exhaled Nitric Oxide Among Children with Asthma and Atopy

Autor: Elmasri, Mary, Romero Rivero, Karina Maribel, Gilman, Robert Hugh, Hansel, Nadia N., Robinson, Colin L., Baumann, Lauren M., Cabrera, Lilia, Hamilton, Robert G., Checkley, William, Combe, Juan, Gomez, Alfonso, Gonzalvez, Guillermo, Barnes, Kathleen, Wise, Robert, Breysse, Patrick, Williams, D'Ann
Rok vydání: 2014
Předmět:
Male
Longitudinal study
Time Factors
atopy
immunoglobulin E
Exhaled nitric oxide
Atopy
ambulatory care
Longitudinal Studies
Lung
clinical article
Confounding
longitudinal study
article
Age Factors
respiratory system
Up-Regulation
female
priority journal
Breath Tests
Exhalation
body height
Biological Markers
Female
Inflammation Mediators
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
interleukin 6
interleukin 5
Nitric Oxide
Article
Predictive Value of Tests
Internal medicine
Hypersensitivity
medicine
follow up
Humans
controlled study
immunoglobulin blood level
human
Asthma
Inflammation
business.industry
Case-control study
asthma
medicine.disease
body mass
respiratory tract diseases
protein blood level
purl.org/pe-repo/ocde/ford#3.02.07 [https]
Case-Control Studies
randomized controlled trial
interleukin 10
expired air
business
Body mass index
Biomarkers
Zdroj: Lung. 192:305-312
ISSN: 1432-1750
0341-2040
DOI: 10.1007/s00408-013-9551-8
Popis: Purpose: Fractional exhaled nitric oxide (FeNO) has emerged as an important biomarker in asthma. Increasing evidence points to atopy as a confounding factor in the interpretation of elevated FeNO. We conducted a longitudinal study to understand the clinical significance of FeNO as an inflammatory biomarker. Methods: We identified 19 children aged 13-15 years at baseline with a significant elevation in FeNO ≥ 80 parts per billion (ppb) and randomly selected a group of children of similar age with a moderate elevation (40-79 ppb) and normal-to-low FeNO (
Databáze: OpenAIRE
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