Brain leptin and nerve growth factor are differently affected by stress in male and female mice: possible neuroendocrine and cardio-metabolic implications
| Autor: | Luigi Aloe, Veronica Di Fausto, Luigi Manni, George N. Chaldakov |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leptin
Male medicine.medical_specialty Thalamus Central nervous system Hypothalamus Adipokine Down-Regulation Receptors Nerve Growth Factor Biology Cardiovascular System Mice Internal medicine Nerve Growth Factor medicine Animals Receptor Sex Characteristics Leptin receptor General Neuroscience digestive oral and skin physiology Brain Neurosecretory Systems Up-Regulation Endocrinology Nerve growth factor medicine.anatomical_structure nervous system Receptors Leptin Female Energy Metabolism hormones hormone substitutes and hormone antagonists Stress Psychological |
| Zdroj: | Neuroscience letters 426 (2007): 39–44. doi:10.1016/j.neulet.2007.08.015 info:cnr-pdr/source/autori:Manni L., Di Fausto V., Chaldakov G.N., Aloe L./titolo:Brain leptin and nerve growth factor are differently affected by stress in male and female mice: possible neuroendocrine and cardio-metabolic implications./doi:10.1016%2Fj.neulet.2007.08.015/rivista:Neuroscience letters (Print)/anno:2007/pagina_da:39/pagina_a:44/intervallo_pagine:39–44/volume:426 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.08.015 |
| Popis: | The aim of the present study was to investigate the variations in leptin and nerve growth factor (NGF) expression induced by immobilization stress in the brain of male and female adult CD1 mice. We found that 10 days of repeated immobilization stress induced an increase of hypothalamus and thalamus NGF that was more pronounced in female than in male mice. We also found that this type of stress induced an increase of leptin expression in the hypothalamus of female mice, and a decrease in the thalamus of both male and female mice, associated with enhanced expression of leptin receptors in the hypothalamus and thalamus, both in male and female mice. The observation that the brain leptin and NGF receptors were altered by stress suggests a functional role for these molecules in neuroendocrine and cardiovascular response to stress events. |
| Databáze: | OpenAIRE |
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