Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT1A and CB1 receptors
| Autor: | Ana Carolina Medeiros, R.B. Malvestio, Sabatino Maione, R.L. de Freitas, Sylmara Esther Negrini-Ferrari, Mariana Oliveira-Silva, L. Luongo, Norberto Cysne Coimbra, Patrícia Medeiros, Cláudia Maria Padovan |
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| Přispěvatelé: | B Malvestio, R, Medeiros, P, E Negrini-Ferrari, S, Oliveira-Silva, M, C Medeiros, A, M Padovan, C, Luongo, L, Maione, S, C Coimbra, N, L de Freitas, R |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
AM251 medicine.medical_specialty Infralimbic cortex 5-HT(1A) serotonergic receptor Chronic neuropathic pain 03 medical and health sciences Mechanical allodynia 0302 clinical medicine Internal medicine Cortex (anatomy) medicine Cannabidiol Depression-associated behaviour Nociception assay Prefrontal cortex SINAPSE business.industry General Neuroscience CB(1) cannabinoid receptor Chronic pain medicine.disease Cobalt chloride Prelimbic medial prefrontal cortex 030104 developmental biology medicine.anatomical_structure Endocrinology Neuropathic pain Forced swim test von Frey test business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2021.06.017 |
| Popis: | The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that is putatively implicated in the chronic pain and depression. We investigated the activity of PrL cortex neurons in Wistar rats that underwent chronic constriction injury (CCI) of sciatic nerve and were further subjected to the forced swimming (FS) test and mechanical allodynia (by von Frey test). The effect of blockade of synapses with cobalt chloride (CoCl2), and the treatment of the PrL cortex with cannabidiol (CBD), the CB1 receptor antagonist AM251 and the 5-HT1A receptor antagonist WAY-100635 were also investigated. Our results showed that CoCl2 decreased the time spent immobile during the FS test but did not alter mechanical allodynia. CBD (at 15, 30 and 60 nmol) in the PrL cortex also decreased the frequency and duration of immobility; however, only the dose of 30 nmol of CBD attenuated mechanical allodynia in rats with chronic NP. AM251 and WAY-100635 in the PrL cortex attenuated the antidepressive and analgesic effect caused by CBD but did not alter the immobility and the mechanical allodynia when administered alone. These data show that the PrL cortex is part of the neural substrate underlying the comorbidity between NP and depression. Also, the previous blockade of CB1 cannabinoid receptors and 5-HT1A serotonergic receptors in the PrL cortex attenuated the antidepressive and analgesics effect of the CBD. They also suggest that CBD could be a potential medicine for the treatment of depressive and pain symptoms in patients with chronic NP/depression comorbidity. |
| Databáze: | OpenAIRE |
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