Clinical assessment of the cancer diagnostic value of prostatic zinc: a comprehensive needle-biopsy study
| Autor: | Gil Raviv, Jacob Ramon, David Vartsky, A. Volkov, Rachel Chechik, Eduard Fridman, E. Moriel, G. Kogan, S. Sh. Shilstein, Marco Cortesi, Amos Breskin, M. Huszar, N. Kleinman, V. Gladysh |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Urology medicine.medical_treatment Biopsy Fine-Needle chemistry.chemical_element Cryotherapy Zinc Adenocarcinoma urologic and male genital diseases Prostate cancer Biopsy Site Prostate Biopsy medicine Humans Computer Simulation Aged Aged 80 and over medicine.diagnostic_test Prostatectomy business.industry Prostatic Neoplasms Spectrometry X-Ray Emission Middle Aged medicine.disease Prostate-specific antigen medicine.anatomical_structure Oncology chemistry ROC Curve business |
| Zdroj: | The Prostate. 68(9) |
| ISSN: | 0270-4137 |
| Popis: | Background The correlation between Zinc concentration in the prostate's peripheral zone to the onset or presence of malignant process needs to be evaluated in detail. Methods Zinc concentration was measured in ∼1–4 mm3 segments of fresh needle-biopsy cores, with X-ray fluorescence, and correlated with the histological findings of these tissue segments. Results Local Zinc concentration is correlated with the presence of cancer (PCa); the higher the Gleason score the greater the Local Zinc depletion. The Zinc value averaged over the entire extracted tissue is specific only to Gleason score 8–9 PCa. The results refer to patients avoiding Zinc-rich supplements since those show elevated prostatic Zinc concentration in identified cancer tissue. A computer simulation analysis of randomly located 0.03–3.3 cm3 lesions, with particular Gleason score and the measured Local Zinc concentration, revealed a potential diagnostic approach definitely superior to PSA, with sensitivity to the tumor grade and with excellent detection capability for Gleason score >6. Further clinical studies have been designed, both on full prostates after radical prostatectomy as well as on biopsy cores at higher resolution, to establish the accuracy of the method for Gleason score = 6. Conclusions The PCa diagnostic potential of Local Zinc concentration is confirmed and there is indication that the amount of Zinc depletion could be used as a measure of the Gleason score of the tumor. Local Zinc concentration mapping has the potential to improve patient selection for biopsy, biopsy site selection and local therapy (e.g., Cryotherapy, Brachytherapy) site selection. Prostate 68:994–1006, 2008. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text