Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy
| Autor: | Daphne P L Lin, Revathy Carnagarin, Crispin R. Dass, Arun Dharmarajan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty JUNB Osteoporosis Pharmaceutical Science Bone Morphogenetic Protein 2 Bone Neoplasms Bone healing Biology Bone morphogenetic protein 2 Bone and Bones Myoblasts 03 medical and health sciences Fractures Bone 0302 clinical medicine Internal medicine medicine Animals Humans Transcription factor Pharmacology Osteoblasts Transdifferentiation Osteoblast medicine.disease Cell biology RUNX2 030104 developmental biology medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Cell Transdifferentiation |
| Zdroj: | The Journal of pharmacy and pharmacology. 69(12) |
| ISSN: | 2042-7158 |
| Popis: | ObjectivesTransdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful.Key findingsThe potent osteoinductive effects of the bone morphogenetic protein-2 are largely implicated in the transdifferentiation of myoblast to osteoblast. Bone morphogenetic protein-2-induced activation of the Smad1 protein ultimately results in JunB synthesis, the first transcriptional step in myoblast dedifferentiation. The upregulation of the activating protein-1 binding activity triggers the transcription of the runt-related transcription factor 2 gene, a transcription factor that plays a major role in osteoblast differentiation.SummaryThis potential transdifferentiation treatment may be utilised for dental implants, fracture healing, osteoporosis and bone repair post-destruction by bone tumours. |
| Databáze: | OpenAIRE |
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